Benzenepropanoic acid, 2-(4-carboxybutoxy)-6-[[(5E)-6-(4-methoxyphenyl)-5-hexen-1-yl]oxy]-

Name	ONO-LB 457
Synonyms	ONO-4057 ONO-LB 457 Benzenepropanoic acid, 2-(4-carboxybutoxy)-6-[[(5E)-6-(4-methoxyphenyl)-5-hexen-1-yl]oxy]-
CAS	134578-96-4

Molecular Formula	C27H34O7
Molar Mass	470.55
Density	1.173±0.06 g/cm3(Predicted)
Boling Point	704.8±60.0 °C(Predicted)
pKa	4.68±0.10(Predicted)
Storage Condition	Room Temprature
In vivo study	Mean animal survivals of the ONO4057-treated animals significantly prolong to 21.0±4.4 days compare with 12.0±0.6 days in control group. Histological findings from grafts taken on day 7 show that severe focal cellular infiltration is observed in both groups, but the degree of hepatocyte necrosis in ONO4057-treated anmimals is milder than that in control group.

biological activity

ONO4057 is an antagonist of the leucotriene B4 receptor with an IC50 value of 0.7±0.3 μm.

Last Update：2024-04-09 20:49:11

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CAS: 134578-96-4
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Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

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Benzenepropanoic acid, 2-(4-carboxybutoxy)-6-[[(5E)-6-(4-methoxyphenyl)-5-hexen-1-yl]oxy]- Request for Quotation